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Chlorotrianisene is a non-steroidal synthetic estrogen that was formerly used for the treatment of menopause, deficiencies in ovary function, and prostate cancer. Chlorotrianisene may react vigorously with strong oxidizing agents. Can react exothermically with reducing agents (such as alkali metals and hydrides) to release gaseous hydrogen. Chlorotrianisene exhibits in vitro little or no binding to the uterine estrogen receptor (ER) but demonstrates potent estrogenic activity in vivo, indicating that Chlorotrianisene is a proestrogen/proantiestrogen. Chlorotrianisene could inhibit bone loss and delay the atrophy of uterus induced by ovariectomy in Wistar female rats. It has protective effects on bone like other estrogen preparations.
| Molecular Weight | 380.86 |
| Formula | C23H21ClO3 |
| CAS Number | 569-57-3 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Estrogen Receptor Products |
|---|
| Fulvestrant
Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect. |
| LY500307
LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM. |
| Calcitriol
Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. *The compound is unstable in solutions, freshly prepared is recommended |
| Tamoxifen Citrate (ICI 46474)
Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. |
| 20-Hydroxyecdysone
20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. |
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