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CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM. CHIR-124 interacts synergistically with camptothecin in causing growth inhibition in MDA-MB-435 cells as determined by isobologram analysis. In HCT116 human colon carcinoma cells, CHIR-124 increased the effect of SN-38, an active metabolite of irinotecan, in a sequence-dependent manner, with the highest induction of mitotic catastrophe and apoptosis seen when CHIR-124 was given sequentially after SN-38 pretreatment. More importantly, the enhancement of cell death by CHIR-124 was markedly increased in isogenic p53-null and p21-null HCT116 cells.
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
CHIR-124 purchased from AbMole
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Source | Proc Natl Acad Sci U S A (2011). Figure 2. CHIR-124 |
| Method | Cell viability assay | |
| Cell Lines | A549 cells | |
| Concentrations | 1 μM | |
| Incubation Time | 72 h | |
| Results | AZD7762 and CHIR-124 increased HDACi-induced cell death of A549 but not LNCaP |
| Molecular Weight | 419.91 |
| Formula | C23H22ClN5O |
| CAS Number | 405168-58-3 |
| Solubility (25°C) | DMSO 7 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Xiaoxue Song, et al. Synergistic targeting of CHK1 and mTOR in MYC-driven tumors
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