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CGP 55845 hydrochloride

Cat. No. M6588

All AbMole products are for research use only, cannot be used for human consumption.

CGP 55845 hydrochloride Structure

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Quality Control & Documentation
Biological Activity

CGP 55845 hydrochloride is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively). Inhibits GABAB responses to baclofen (IC50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro.

Chemical Information
Molecular Weight 438.71
Formula C18H22Cl2NO3P.HCl
CAS Number 149184-22-5
Solubility (25°C) DMSO 43.87 mg/mL (with gentle warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Cherednichenko, et al. Circ Res. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release.

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Keywords: CGP 55845 hydrochloride supplier, inhibitors, activators

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