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CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM). CGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.
| Molecular Weight | 384.24 |
| Formula | C15H24Cl2NO4P |
| CAS Number | 139667-74-6 |
| Solubility (25°C) | DMSO 4 mg/mL Water 2 mg/mL (with sonication) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GABA Receptor Products |
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| Alpidem
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| (R)-Baclofen
(R)-baclofen, a gamma-aminobutyric acid derivative and agonist at GABA-B receptors, inhibits nerve conduction in the central nervous system and can be used in studies related to spasticity. |
| (+)-Bicuculline
(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| Bemegride
Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning. |
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