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Cetirizine is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist.
In vivo, Cetirizine (20 mg/kg, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen.
| Molecular Weight | 388.89 |
| Formula | C21H25ClN2O3 |
| CAS Number | 83881-51-0 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | 4°C, protect from light |
| Related Histamine Receptor Products |
|---|
| Ciproxifan maleate
Ciproxifan is an orally bioavailable, extremely potent histamine H3 inverse agonist/antagonist. |
| Antazoline hydrochloride
Antazoline hydrochloride is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine. |
| Azacyclonol
Azacyclonol, also known as γ-pipradol, which diminishes hallucinations in psychotic individuals. |
| Azatadine dimaleate
Azatadine dimaleate is an antihistamine and anticholinergic compound with IC50 of 6.5nM and 10nM, respectively. |
| Bepotastine Besilate
Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7. |
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