All AbMole products are for research use only, cannot be used for human consumption.
Ceruletide is similar chemically and biologically to the human gastrointestinal hormones cholecystokinin-pancreozymin (CCK) and gastrin II.
In vivo, Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) results in emesis and evacuation of the bowel in the intact conscious dog, and recovery is complete 15-30 min after i. v. administration and 2-4 hr after s.c. administration. Ceruletide (5-15 ng/kg, i.v.) shows a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduces blood pressure in anesthetized dogs.
Cell Signal. 2024 Nov 20;126:111518.
Sestrin2 balances mitophagy and apoptosis through the PINK1-Parkin pathway to attenuate severe acute pancreatitis
Ceruletide purchased from AbMole
J Interferon Cytokine Res. 2023 Oct;43(10):455-468.
The Role and Potential Regulatory Mechanism of STING Modulated Macrophage Apoptosis and Differentiation in Severe Acute Pancreatitis-Associated Lung Injury
Ceruletide purchased from AbMole
Basic Clin Pharmacol Toxicol. 2021 Nov;129(5):357-368.
RORγt inhibitor SR1001 alleviates acute pancreatitis by suppressing pancreatic IL‐17‐producing Th17 and γδ‐T cells in mice with ceruletide‐induced pancreatitis
Ceruletide purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Human bronchial epithelial cells |
| Preparation method | In brief, to select the proper final doses, human bronchial epithelial cells were cultured with lapiferin or ceruletide at various doses for 24 h and then the cell supernatants were collected and subjected to ELISA detection of pro-inflammatory factors IL-1β and TNFα. |
| Concentrations | 2 μg/mL |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male C57BL/6J mice |
| Formulation | Saline |
| Dosages | 50 μg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 1352.41 |
| Formula | C58H73N13O21S2 |
| CAS Number | 17650-98-5 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL Water 2 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[2] Steinle AU, et al. Gastroenterology. NF-kappaB/Rel activation in cerulein pancreatitis.
| Related Cholecystokinin Receptor Products |
|---|
| Pentagastrin
Pentagastrin (ICI-50123) is a synthetic polypeptide that has effects like gastrin when given parenterally. |
| Proglumide sodium salt
Proglumide sodium salt is a non-selective, orally active cholecystokinin (CCK) antagonist. |
| Lintitript
Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM). |
| Lorglumide sodium salt
Lorglumide (CR-1409) sodium salt is a potent cholecystokinin (CCK) receptor antagonist. |
| Gastrin-I (human)
Gastrin-I (human) is the endogenous peptide produced in the stomach, which increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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