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Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.
| Molecular Weight | 481.53 |
| Formula | C26H33FNNaO5 |
| CAS Number | 143201-11-0 |
| Form | Solid |
| Solubility (25°C) | Water 100 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | -20°C, protect from light, sealed |
[1] Stephen P Adams, et al. Cochrane Database Syst Rev. Cerivastatin for lowering lipids
[2] A Cheng-Lai. Heart Dis. Cerivastatin
[3] W Mück. Clin Pharmacokinet. Clinical pharmacokinetics of cerivastatin
| Related HMG-CoA Reductase Products |
|---|
| Fluvastatin sodium
Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor with IC50 value between 40 and 100 nM at human liver microsomes. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. |
| Rosuvastatin calcium
Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. |
| Mevastatin
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| Pravastatin sodium
Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
| Clinofibrate
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
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