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CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. Additionally CDN1163 induces significant reduction in adipose tissue weight with no change in lean mass in ob/ob mice. CDN1163 has no effect on glucose levels or body weight in lean control mice.
| Cell Experiment | |
|---|---|
| Cell lines | N2A cells |
| Preparation method | N2A cells were cultured in 6-well dishes and were treated with DMSO or 10 μM CDN1163 for 3 days. Cells were harvested, fixed in 70 % ethanol and kept at −20°C overnight. |
| Concentrations | 10 μM |
| Incubation time | 3 days |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J |
| Formulation | 5% DMSO, 40% PEG400, 10% Tween 80, and 40% saline. |
| Dosages | 50 mg/kg/day |
| Administration | Intraperitoneal injection |
| Molecular Weight | 320.39 |
| Formula | C20H20N2O2 |
| CAS Number | 892711-75-0 |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Giacomo Sordi, et al. Stimulation of Ca 2+ -ATPase Transport Activity by a Small-Molecule Drug
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