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CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models.
CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging of 85-170 nM.
| Molecular Weight | 572.7 |
| Formula | C33H43F3N2O3 |
| CAS Number | 932730-52-4 |
| Form | Solid |
| Storage | Store at -20°C |
| Related Keap1-Nrf2 Products |
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| Sulforaphane
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. |
| Ginsenoside-Rh3
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 induces Nrf2 activation in human retinal cells. |
| Astilbin
Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation. |
| Luteolin
Luteolin (Luteolol) is a natural flavonoid that is a modulator of Nrf2. Luteolin exhibits dual regulation of Nrf2. In tumour cells, low concentrations of Luteolin activate the Nrf2 signalling pathway and promote Nrf2 nuclear translocation, while high concentrations of Luteolin inhibit Nrf2 activity and negatively modulate the Nrf2/ARE signalling pathway. Luteolin is also a PDE inhibitor. In addition, Luteolin has a variety of biological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotection. Luteolin can be used in studies related to ferroptosis. |
| ML 334
ML334 (LH601A) is a inhibitor of Keap1- Nrf2 interaction. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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