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CD532 

Cat. No. M28750

All AbMole products are for research use only, cannot be used for human consumption.

CD532  Structure

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Quality Control & Documentation
Biological Activity

CD532 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 also can directly interact with AURKA and induces a global conformational shift. CD532 can be used for the research of cancer.

Chemical Information
Molecular Weight 522.52
Formula C26H25F3N8O
CAS Number 1639009-81-6
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Hua Ye, et al. Int J Gen Med. Gene Network Analysis of Hepatocellular Carcinoma Identifies Modules Associated with Disease Progression, Survival, and Chemo Drug Resistance

[2] Zahra Musavizadeh, et al. Biomolecules. Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A

[3] James A H Gilburt, et al. Angew Chem Int Ed Engl. Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy

[4] Richard Bayliss, et al. Biochem Soc Trans. A moving target: structure and disorder in pursuit of Myc inhibitors

[5] Mark W Richards, et al. Proc Natl Acad Sci U S A. Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

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  Catalog
Abmole Inhibitor Catalog




Keywords: CD532  supplier, Aurora Kinase, inhibitors, activators

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