Free shipping on all orders over $ 500

TRAF-STOP inhibitor 6877002

Cat. No. M8459

All AbMole products are for research use only, cannot be used for human consumption.

TRAF-STOP inhibitor 6877002 Structure
Synonym:

CD40-TRAF6 signaling inhibitor

Size Price Availability Quantity
5mg USD 55 In stock
10mg USD 75 In stock
25mg USD 165 In stock
50mg USD 295 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

TRAF-STOP inhibitor 6877002 is a small molecule that binds to TRAF6, blocking interactions with CD40. TRAF-STOP inhibitor 6877002 inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. TRAF-STOP inhibitor 6877002 reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

Chemical Information
Molecular Weight 251.32
Formula C17H17NO
CAS Number 433249-94-6
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lena Bosch, et al. Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

[2] Suzanne A B M Aarts, et al. Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

[3] Jose-Andres C Portillo, et al. Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling

[4] Jose-Andres C Portillo, et al. Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells

[5] Antonios Chatzigeorgiou, et al. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

Related Products
Lactate calcium

Lactate calcium is an excellent calcium fortifier that works better than inorganic calcium. Lactate calcium is used as an antacid.

Coniferyl ferulate

Coniferyl ferulate is a potent glutathione S-transferase (GST) inhibitor that reverses multidrug resistance and down-regulates p-glycoprotein. Coniferyl ferulate strongly inhibited human placental glutathione S-transferase with IC50 of 0.3 μM.

NXY-059

NXY-059 is a free radical-trapping neuroprotectant that has been reported to reduce infarct size and preserve brain function in experimental models of acute ischemic stroke.

Tie2 kinase inhibitor

Tie2 kinase inhibitor is a potent, reversible, and ATP-binding site-targeting Tie2 inhibitor with an IC50 of 250 nM.

Calcium levofolinate

Calcium levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.

  Catalog
Abmole Inhibitor Catalog




Keywords: TRAF-STOP inhibitor 6877002, CD40-TRAF6 signaling inhibitor supplier, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.