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CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
| Molecular Weight | 347.84 |
| Formula | C21H18ClN3 |
| CAS Number | 305372-78-5 |
| Solubility (25°C) | DMSO: ≥20 mg/mL (warm to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Rohit Mathur, et al. Targeting Wnt pathway in mantle cell lymphoma-initiating cells
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