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CCR2 antagonist 5 

Cat. No. M27990

All AbMole products are for research use only, cannot be used for human consumption.

CCR2 antagonist 5  Structure

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Quality Control & Documentation
Biological Activity

CCR2 antagonist 5 is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). CCR2 antagonist 5 displays a Ki of 9.6 µM for mCCR2 binding. CCR2 antagonist 5 can be used in the research of inflammatory disease.

Chemical Information
Molecular Weight 482.52
Formula C22H25F3N4O3S
CAS Number 1228650-83-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Tobias Puengel, et al. Int J Mol Sci. Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis

[2] Ruaa Al-Qazazi, et al. Am J Respir Crit Care Med. Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension

[3] Ronghui Lin, et al. J Labelled Comp Radiopharm. Synthesis of deuterium-labeled CCR2 antagonist JNJ-26131300, [4-(1H-indol- 3-yl)-piperidin-1-yl]-{1-[3-(3,4,5-trifluoro-phenyl)-acryloyl]-piperidin-4-yl}-acetic acid

[4] Aditya Ambade, et al. Hepatology. Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice

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Keywords: CCR2 antagonist 5  supplier, CCR, inhibitors, activators

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