All AbMole products are for research use only, cannot be used for human consumption.
CCF642 is a cell-permeable protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action that most likely involves PDI active-site CGHCK motifs instead of cysteine known to be targeted by PACMA 31. CCF642 displays anti-multiple myeloma (MM) activity both in cultures in vitro (IC50 <1 μM against murine 5TGM1 and nine human MM lines) and in mice in vivo (10 mg/kg, 3X i.p. per wk) without apparent adverse effects to the animals or being cytotoxic to normal bone marrow (NLBM) cells even at concentrations as high as 6.75 μM. Consistent with PDI′s role in ER protein folding process, CCF642 treatment causes acute ER stress accompanied by apoptosis-inducing calcium release in MM cells.
| Molecular Weight | 378.45 |
| Formula | C15H10N2O4S3 |
| CAS Number | 346640-08-2 |
| Form | Solid |
| Solubility (25°C) | DMSO: 5 mg/mL (warmed) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Apoptosis Products |
|---|
| 23-Hydroxybetulinic acid
23-Hydroxybetulinic acid is a novel anticancer substance. |
| TH-302 (Evofosfamide)
TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
| Se-Methylselenocysteine
Se-methylselenocysteine, a precursor of methyl selenium, has strong cancer chemoprophylaxis and antioxidant activity. Se-Methylselenocysteine has oral biological activity, can induce apoptosis. |
| Aloperine
Aloperine is exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. |
| Ezatiostat
Ezatiostat (TER199, TLK199) is a glutathione analog inhibitor of glutathione S-transferase (GST) P1-1. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
