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CCCP is a widely used uncoupler of oxidative phosphorylation. CCCP impairs the interaction between STING and TBK1 and concomitantly triggers mitochondria fission. Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated mitochondria fragmentation. The protonophore CCCP that disrupts membrane potential suppresses the DMXAA-triggered STING signaling pathway.
In cells treated with 10-100 μM CCCP, which is the dose used for inducing mitophagy, mitocytosis is barely induced. Mechanistically, mitocytosis requires positioning of damaged mitochondria at the cell periphery, which occurs because damaged mitochondria avoid binding to inward motor proteins
| Molecular Weight | 204.62 |
| Formula | C9H5ClN4 |
| CAS Number | 555-60-2 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage | -20°C, sealed |
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