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CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity.
CCB02 (30 mg/kg, p.o. daily for 24 days) shows potent anti-tumor effect in nude mice bearing subcutaneous human lung (H1975T790M cells) tumor xenografts.
| Molecular Weight | 235.24 |
| Formula | C14H9N3O |
| CAS Number | 2100864-57-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 24 mg/mL |
| Storage | -20°C, sealed |
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