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Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, demonstrating inhibition of mTORC1 (pS6RP and p4EBP1) and mTORC2 [pAKT(S473)] in cellular systems. CC-223 competitively inhibits the mTOR kinase that targets mTORC1 and mTORC2, prevents upregulation of AKT phosphorylation, differentiating it from the rapalogs. CC-223, with superior physicochem-ical and pharmacokinetic properties, excellent kinase selectivity, demonstrates efficacy across multiple solid tumor models with oral dosing.
| Molecular Weight | 397.47 |
| Formula | C21H27N5O3 |
| CAS Number | 1228013-30-6 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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