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CB2 receptor agonist 3

Cat. No. M30911

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CB2 receptor agonist 3 Structure
Synonym:

GP2a

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Quality Control & Documentation
Biological Activity

CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells.

Chemical Information
Molecular Weight 440.36
Formula C24H23Cl2N3O
CAS Number 919077-81-9
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tapio Nevalainen. Curr Med Chem. Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands

[2] Stewart Christie, et al. Am J Physiol Renal Physiol. CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder

[3] Xiaoting Li, et al. Cell. Crystal Structure of the Human Cannabinoid Receptor CB2

[4] Qi-Wen Han, et al. Acta Pharmacol Sin. CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways

[5] Thanh C Ho, et al. Bioorg Med Chem Lett. Oxa-adamantyl cannabinoids

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Keywords: CB2 receptor agonist 3, GP2a supplier, Cannabinoid, inhibitors, activators

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