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CAY10566 is a potent and selective inhibitor of SCD1 (stearoyl-CoA desaturase1) that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. CAY10566 treatment decreases Swiss 3T3 cell proliferation with concentration of 0.0001-10 μM. CAY10566 (2.5 mg/kg; orally twice daily) has great effect on mice with tumors.
| Molecular Weight | 389.81 |
| Formula | C18H17ClFN5O2 |
| CAS Number | 944808-88-2 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Stearoyl-CoA Desaturase Products |
|---|
| MK-8245
MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. |
| Aramchol
Aramchol is a novel fatty acid bile acid coupling agent with oral activity and an inhibitor of SCD1, which acts by inhibiting SCD1 expression in hepatocytes and hepatic astrocytes, and can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| CVT-12012
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. |
| GSK1940029
GSK1940029 (SCD inhibitor 1) is a potent acyl-CoA desaturase (SCD) inhibitor. |
| A939572
A939572 is a potent, orally active stearyl CoA desaturase 1 SCD1 inhibitor that acts on mSCD1 and hSCD1 with IC50 <4 nM and 37 nM, respectively. |
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Products are for research use only. Not for human use. We do not sell to patients.
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