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CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1.
| Molecular Weight | 311.15 |
| Formula | C12H7BrO3S |
| CAS Number | 938069-71-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 66.67 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light, dry, sealed |
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