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Cathepsin B

Cat. No. M43194

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Cathepsin B Structure
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5U USD 400 In stock
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Biological Activity

Cathepsin B is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death). Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.

Chemical Information
CAS Number 9047-22-7
Form Lyophilized powder
Storage -20°C
References

[1] Gregory Hook et al. Pharmacol Rev. Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

[2] J S Mort et al. Int J Biochem Cell Biol. Cathepsin B

[3] Olja Mijanović et al. Cancer Lett. Cathepsin B: A sellsword of cancer progression

[4] Zhe Lin et al. Cell Res. Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis

[5] Zhen Xie et al. Cell Death Dis. Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

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