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Catharanthine is a precursor of vinblastine-type alkaloids, found to have antitumor activity.Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.catharanthine can induce the self-association of tubulin into linear indefinite polymers with an efficacy that is 75% that of vinblastine or vincristine, the intrinsic dimerization constant for the liganded protein being K2 congruent to 1 x 10(5) M-1.
| Molecular Weight | 434.51 |
| Formula | C21H24N2O2.H2SO4 |
| CAS Number | 70674-90-7 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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