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Casimersen (SRP-4045) is an antisense oligonucleotide of the subclass of phosphodiamide morphorph oligomers. Casimersen binds to exon 45 of dystrophin's precursor mRNA to restore the open reading frame (by skipping exon 45), resulting in an internally truncated but functional dystrophin. Casimersen can be used in the study of Duchenne muscular dystrophy (DMD).
| Molecular Weight | 7584.00 |
| CAS Number | 1422958-19-7 |
| Solubility (25°C) | Water ≥ 60 mg/mL |
| Storage | -20°C, dry, sealed |
[1] No authors listed. Casimersen
[2] H Wilton-Clark, et al. Drugs Today (Barc). Casimersen for Duchenne muscular dystrophy
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