All AbMole products are for research use only, cannot be used for human consumption.
Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.
Immobilized Human Endoglin/CD105 at 2 μg/mL (30 μL/well) can bind carotuximab with the EC50 of 0.04398 μg/mL.
| CAS Number | 1268714-50-6 |
| Storage | Store at ≤ -20℃ for 24 months. Avoid repeated freeze-thaw cycles. |
[2] Kuo-Shyang Jeng, et al. Int J Mol Sci. The Role of Endoglin in Hepatocellular Carcinoma
[3] Mark J A Schoonderwoerd, et al. Biomolecules. Endoglin: Beyond the Endothelium
| Related TGF-beta/Smad Products |
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| Pirfenidone
Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (AMR69) attenuates CCL2 and CCL12 production in fibrocyte cells. |
| Asiaticoside
Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. |
| Amygdalin
Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. |
| Norcantharidin
Norcantharidin |
| Kartogenin
Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
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Products are for research use only. Not for human use. We do not sell to patients.
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