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Carboxyamidotriazole

Cat. No. M8330

All AbMole products are for research use only, cannot be used for human consumption.

Carboxyamidotriazole Structure
Synonym:

L-651582; CAI

Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 150 In stock
25mg USD 270 In stock
50mg USD 400 In stock
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Biological Activity

Carboxyamidotriazole (L-651582) is an orally active calcium channel blocker. Carboxyamidotriazole blocks intracellular and mitochondrial calcium entry and flux, resulting in inhibition of cell proliferation, calcium-release-activated calcium channel (CRAC) function, and maintenance of mitochondrial membrane potential.

Chemical Information
Molecular Weight 424.67
Formula C17H12Cl3N5O2
CAS Number 99519-84-3
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shan Lu, et al. Carboxyamidotriazole exerts anti-inflammatory activity in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPKs pathways

[2] PLOS ONE Editors. Retraction: Carboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis

[3] Jing Shi, et al. Carboxyamidotriazole combined with IDO1-Kyn-AhR pathway inhibitors profoundly enhances cancer immunotherapy

[4] Manjulika Das. Carboxyamidotriazole orotate in glioblastoma

[5] Olivier Mignen, et al. Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells

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Keywords: Carboxyamidotriazole, L-651582; CAI supplier, Calcium Channel, inhibitors, activators

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