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Carbetocin acetate is an oxytocin (OT) analog and oxytocin receptor agonist that crosses the blood-brain barrier with a Ki of 7.1 nM. In addition, Carbetocin acetate has a high affinity for the chimeric N-terminal (E1) end of the oxytocin receptor, with a Ki = 1.17 μM. Carbetocin acetate can be used in studies related to postpartum hemorrhage.
| Molecular Weight | 1048.21 |
| Formula | C47H73N11O14S |
| CAS Number | 1631754-28-3 |
| Form | Solid |
| Solubility (25°C) | DMSO >100 mg/mL Water 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Oxytocin Receptor Products |
|---|
| Cligosiban
Cligosiban (PF-3274167) is a high-affinity, high oral bioavailability and good brain-penetrant nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM. |
| Oxytocin acetate
Oxytocin acetate, a mammalian neurohypophysial hormone, is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma. |
| Carbetocin
Carbetocin is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS. |
| L-368,899 hydrochloride
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. |
| Atosiban
Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research. |
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