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Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA.
| Molecular Weight | 167.21 |
| Formula | C12H9N |
| CAS Number | 86-74-8 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 150 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Feng Song et al. Arch Pharm (Weinheim). The anticancer activity of carbazole alkaloids
[2] Alena Gabelova. Chem Biol Interact. 7H-Dibenzo[c,g]carbazole: Metabolic pathways and toxicity
[3] D P Chakraborty et al. Fortschr Chem Org Naturst. Carbazole alkaloids. IV
[4] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Carbazole
[5] D P Chakraborty et al. Fortschr Chem Org Naturst. Carbazole alkaloids. III
| Related DNA/RNA Synthesis Products |
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Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| Nelarabine
Nelarabine is a novel purine antimetabolite antineoplastic agent. |
| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| Capecitabine
Capecitabine is an orally-administered chemotherapeutic agent. Capecitabine is a precursor, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. Capecitabine may inhibit cytochrome CYP2C9 enzyme, and therefore increase levels of substrates such as phenytoin and other substrates of CYP2C9. |
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