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Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. Carbacyclin activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart.
| Molecular Weight | 350.49 |
| Formula | C21H34O4 |
| CAS Number | 69552-46-1 |
| Form | Solid |
| Solubility (25°C) | Soluble in ethanol |
| Storage | Powder -20°C |
| Related Prostaglandin Receptor Products |
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