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Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
| Cell Experiment | |
|---|---|
| Cell lines | BHK-21 cells |
| Preparation method | The cells were either pre-incubated for 2 h with inhibitor (50 mM Ammonium chloride, 100 µM Camostat mesylate or a combination of both; cell treated with DMSO served as controls) before transduction or directly inoculated with pseudotype particles bearing SARS-2-S. |
| Concentrations | 100 µM |
| Incubation time | 2 h |
| Animal Experiment | |
|---|---|
| Animal models | BALB/C mice |
| Formulation | Water |
| Dosages | 30 mg/kg twice daily |
| Administration | Oral gavage |
| Molecular Weight | 494.52 |
| Formula | C20H22N4O5.CH4O3S |
| CAS Number | 59721-29-8 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Serap Şimşek-Yavuz, et al. An update of anti-viral treatment of COVID-19
[3] Dwight L McKee, et al. Candidate drugs against SARS-CoV-2 and COVID-19
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