All AbMole products are for research use only, cannot be used for human consumption.
Calicheamicins target DNA and cause strand scission. Calicheamicins bind with DNA in the minor groove, wherein they then undergo a reaction analogous to the Bergman cyclization to generate a diradical species. The specificity of binding of calicheamicin to the minor groove of DNA was demonstrated by Crothers et al. (1999) to be due to the aryltetrasaccharide group of the molecule.
| Molecular Weight | 1368.34 |
| Formula | C55H74IN3O21S4 |
| CAS Number | 108212-75-5 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA Alkylator/Crosslinker Products |
|---|
| Apaziquone
Apaziquone is a bioreductive procompound and a chemical analog of the older chemotherapeutic agent mitomycin C. |
| Bendamustine hydrochloride
Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity. |
| Dacarbazine
Dacarbazine (DTIC-Dome; DTIC) is an alkylating agent that acts as a purine nucleotide precursor analog to inhibit purine nucleotide synthesis, thereby inhibiting DNA/RNA Synthesis, and can be used in studies related to melanoma and Hodgkin's lymphoma. |
| Altretamine
Altretamine is an antitumor agent which also acts as a chemosterilant for male houseflies and other insects. |
| Carmustine
Carmustine is an alkylating antineoplastic agent for inhibiting the growth of U87MG glioblastoma cells with IC50 of 1.42 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
