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Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment.
| Molecular Weight | 443.41 |
| Formula | C25H28Cl2N2O |
| CAS Number | 2387505-78-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Calcium-sensing Receptor Products |
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| Cinacalcet HCl
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