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Calcipotriol increased hCAP18 mRNA expression in IL-17/IL-22-stimulated keratinocytes. However, LL37 peptide in the culture supernatants was reduced by calcipotriol. Calcipotriol and FTY720 augment IL-2-activated NK cell lysis of K562 and RAJI tumor cell lines as well as immature (i) and mature (m) DCs, with variable efficacies. Vitamin D3, calcipotriol and FTY720 enhance NK17/NK1 cell lysis of K562 cells, suggesting that a possible mechanism of action for these drugs is via activating these newly described cells. MC903 (calcipotriol) is a novel vitamin D3 analogue which is at least 100 times less potent than 1,25-(OH)-2-D3 in its effects on calcium homeostasis.
*The compound is unstable in solutions, freshly prepared is recommended
| Cell Experiment | |
|---|---|
| Cell lines | HEK001 keratinocytes |
| Preparation method | Cells were treated with vehicle or Calcipotriol (1, 10, 100 μM) for 24 hours. Protein concentrations of whole-cell lysates were normalized by Bradford assay. |
| Concentrations | 1, 10, 100 μM |
| Incubation time | 24 hours |
| Animal Experiment | |
|---|---|
| Animal models | Adult male Swiss albino mice |
| Formulation | Not mentioned |
| Dosages | 20, 60 and 80 µg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 412.6 |
| Formula | C27H40O3 |
| CAS Number | 112965-21-6 |
| Solubility (25°C) | DMSO 90 mg/mL Ethanol 40 mg/mL |
| Storage | -20°C, protect from light, sealed |
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