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Caffeic acid inhibited 5-lipoxygenase in a non-competitive manner. Caffeic acid and its methyl ester did not inhibit prostaglandin synthase activity at all, at least up to 5 X 10(-4) M, but rather stimulate at higher doses.Caffeic acid has been shown to inhibit arachidonic acid metabolism in platelets at high doses.It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.Caffeic acid inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy.Caffeic acid inhibits Cu2+-induced LDL oxidation.
| Molecular Weight | 180.16 |
| Formula | C9H8O4 |
| CAS Number | 331-39-5 |
| Solubility (25°C) | DMSO 40mg/mL Ethanol 25mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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