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Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes. Cadisegliatin did not cause hypoglycemia, had no detrimental effect on plasma lipids or liver enzymes, and did not increase blood pressure, highlighting the importance of tissue selectivity and preservation of physiological regulation when targeting key metabolic regulators such as GK.
| Molecular Weight | 455.63 |
| Formula | C21H33N3O4S2 |
| CAS Number | 859525-02-3 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 4°C, protect from light |
| Related Glucokinase (GK) Products |
|---|
| LY2608204
LY2608204 activates glucokinase (GK) with EC50 of 42 nM. |
| AM2394
AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM. |
| Dorzagliatin
Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a glucokinase (GK) activator, which improves glycaemic control and pancreatic β-cell function for type 2 diabetes. |
| AZD1656
AZD1656 is a potent, selective and orally active glucokinase (GK) activator, with an EC50 of 60 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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