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CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).
| Molecular Weight | 347.43 |
| Formula | C18H21NO4S |
| CAS Number | 407587-33-1 |
| Solubility (25°C) | DMSO 34.74 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Chloride Channel Products |
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| Atractyloside potassium salt
Atractyloside potassium salt is a highly effective and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibited the chloride channel in rat heart mitochondrial membrane. Atractyloside potassium salt is a toxic diterpenoid glycoside, which can be isolated from the fruit of Atractyloside. |
| Eact
Eact is a activator of Ca 2+-activated Cl - channel transmembrane protein 16A (TMEM16A). |
| NPPB
NPPB is a blocker of the outwardly rectifying chloride channel (ORCC) with IC50 of 80 nM. NPPB has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization. |
| T16Ainh-A01
T16Ainh-A01 is a Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. |
| Ani9
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. |
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