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Cabozantinib has weak inhibitory activity against RON and PDGFRβ with IC50 of 124 nM and 234 nM, respectivey, and has low activity against FGFR1 with IC50 of 5.294 μM.Cabozantinib also decreases invasiveness of primary tumors and reduces metastasis.Cabozantinib at 30 mg/kg/day significantly abrogates human MPNST xenografts growth and metastasis in SCID mice.
| Molecular Weight | 635.59 |
| Formula | C28H24FN3O5.C4H6O5 |
| CAS Number | 1140909-48-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related VEGFR/PDGFR Products |
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| Axitinib
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| Regorafenib
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| Nintedanib
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