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C646 is a selective inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. C646 preferentially selective for p300 versus other acetyltransferases.
C646 treatment reduces histone H3 and H4 acetylation levels and abrogates TSA-induced acetylation in cells. C646 has a more potent effect on cell growth than Lys-CoA-Tat does. C646 enhances mitotic catastrophe after IR and suppresses phosphorylation of CHK1 after IRin A549 cells. C646 attenuates the increased acetylation of GATA1 and the increased transcriptional activity of GATA1 induced by EDAG.
In vivo, suppression of P300 by c646 (intraperitoneally injected, 30 nmol/g/d for 2 weeks) dramatically reduces the level of blood glucose in db/db mice.
Mol Neurobiol. 2025 Dec 15;63:295.
Tauroursodeoxycholic Acid Inhibits NF-κB/p300/H3K14ac to Attenuate Microglial Activation in Lipopolysaccharide-treated BV-2 Cells and Mice.
C646 purchased from AbMole
| Molecular Weight | 445.42 |
| Formula | C24H19N3O6 |
| CAS Number | 328968-36-1 |
| Solubility (25°C) | DMSO 9 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Fang Fang, et al. C646 modulates inflammatory response and antibacterial activity of macrophage
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Products are for research use only. Not for human use. We do not sell to patients.
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