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C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.
| Cell Experiment | |
|---|---|
| Cell lines | H9C2 cells |
| Preparation method | Inhibition of TRAF6 attenuated LPS-mediated myocardial injury. The H9C2 cardiomyocytes were pretreated with C25-140 (5 μM, an inhibitor of TRAF6) for 2 h and then treated with LPS (10 μg/ml) and Deh (10 μg/ml) for 24 h. |
| Concentrations | 2 h |
| Incubation time | 5 μM |
| Animal Experiment | |
|---|---|
| Animal models | Male Kunming mouse |
| Formulation | Not mentioned |
| Dosages | 10 mg/kg |
| Administration | i.p. |
| Molecular Weight | 457.57 |
| Formula | C26H31N7O |
| CAS Number | 1358099-18-9 |
| Solubility (25°C) | DMSO 62.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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