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C2 Ceramide (N-Acetyl-D-sphingosine) is a cell-permeable and biologically active ceramide, it induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases. C2 Ceramide (N-Acetyl-D-sphingosine) produces concentration-dependent impairment of vasorelaxation in response to the endothelium-dependent agonist acetylcholine in nontransgenic mice.
| Molecular Weight | 341.53 |
| Formula | C20H39NO3 |
| CAS Number | 3102-57-6 |
| Solubility (25°C) | Soluble in DMSO Soluble in ethanol |
| Storage | -20°C, dry, sealed |
[1] P A Hill, et al. J Endocrinol. Ceramide-induced cell death/survival in murine osteoblasts
[2] R T Dobrowsky, et al. J Biol Chem. Ceramide activates heterotrimeric protein phosphatase 2A
[3] R T Dobrowsky, et al. J Biol Chem. Ceramide stimulates a cytosolic protein phosphatase
| Related Phosphatase Products |
|---|
| CCT007093
CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
| Microcystin-LR
Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| Sal003
Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. |
| Razuprotafib
Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM). |
| β-Glycerophosphate disodium salt hydrate
β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. |
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