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C16 is a pKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.
| Molecular Weight | 268.29 |
| Formula | C13H8N4OS |
| CAS Number | 608512-97-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 13 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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