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C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation. C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. C-178 decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.
| Molecular Weight | 322.27 |
| Formula | C17H10N2O5 |
| CAS Number | 329198-87-0 |
| Solubility (25°C) | DMSO ≥ 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Simone M Haag, et al. Nature. Targeting STING with covalent small-molecule inhibitors
| Related STING Products |
|---|
| Vadimezan
Vadimezan (DMXAA; ASA-404) acts as a tumor vascular disrupting agent (tumor-VDA), is also a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. |
| G10
G10 is a activator of STING-dependent signaling. |
| 3′3′-cGAMP
3',3'-cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. 3',3'-cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators. |
| diABZI (tautomerism)
diABZI (STING agonist 1; Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
| C-176
C-176 is a potent, selective and blood-brain barrier permeable inhibitor of STING. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING. |
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