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C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 (1 mg/kg; i.p.; daily; for 3 days) significantly less microgliosis in acute liver failure mice.
| Molecular Weight | 467.65 |
| Formula | C27H41N5O2 |
| CAS Number | 864289-85-0 |
| Solubility (25°C) | DMSO 45 mg/mL Ethanol 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CCR Products |
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| Bindarit
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| BMS-813160
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| INCB3284 dimesylate
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