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BYK 49187 is a pARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro; reduces myocardial infarct size in vivo.
| Molecular Weight | 335.4 |
| Formula | C19H21N5O |
| CAS Number | 163120-31-8 |
| Solubility (25°C) | DMSO 3.35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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