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BVT 2733 is a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that protects osteoblasts against endogenous glucocorticoid induced dysfunction. BVT 2733 is potently against the mouse enzyme (IC50=96 nM) over the human enzyme (IC50=3341 nM). BVT 2733 (50-100 μM; 24 hours) reduces the inflammation protein levels (MCP-1, IL-6) in medium in J774.1 macrophages.
BVT 2733 lowers blood glucose levels in in hyperglycaemic mice. BVT-2733 (oral administration; 100 mg/kg; twice daily; 2 weeks) attenuates the arthritis severity and anti-CII level and decreases the levels of serum TNF-α, IL-1β, IL-6 and IL-17 in CIA mice.
| Molecular Weight | 428.96 |
| Formula | C17H21ClN4O3S2 |
| CAS Number | 376640-41-4 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Yu Xie, et al. Mechanism of BVT.2733 and pioglitazone in the improvement of insulin resistance
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