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Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator. Induces apoptosis in B16 melanoma cells and HL-60 human leukemia cells.
| Molecular Weight | 272.25 |
| Formula | C15H12O5 |
| CAS Number | 487-52-5 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Renalison Farias-Pereira, et al. Butein inhibits lipogenesis in Caenorhabditis elegans
[4] Ganesan Padmavathi, et al. Butein in health and disease: A comprehensive review
[5] Ganesan Padmavathi, et al. Potential of butein, a tetrahydroxychalcone to obliterate cancer
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