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Bulevirtide is a first-in-class entry inhibitor for the treatment of chronic Hepatitis D infection. Bulevirtide prevents Hepatitis D entry into cells. It is effective in the reduction of Hepatitis D virus (HDV) RNA levels and improvement of liver inflammation in cases of Hepatitis D infection. In rats, bulevirtide administered by subcutaneous injection is rapidly absorbed with a Cmax of 4 to 6 hours.
Int J Biol Macromol. 2023 Jun 22;245:125539.
Strongylocentrotus nudus egg polysaccharide (SEP) suppresses HBV replication via activation of TLR4-induced immune pathway
Bulevirtide purchased from AbMole
| CAS Number | 2012558-47-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] D Yardeni, et al. Drugs Today (Barc). Bulevirtide for HBV and HDV infections
[4] Connie Kang, et al. Drugs. Bulevirtide: First Approval
[5] Christopher Koh, et al. Clin Liver Dis. HBV/HDV Coinfection: A Challenge for Therapeutics
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