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Bufexamac is an enzyme cyclooxygenase and HDAC6/HDAC10 inhibitor for the secretion of IFN-α with an EC50 of 8.9 μM. Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with Bufexamac prevents the secretion of IFN-α. Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug. Bufexamac is a specific inhibitor of class IIB histone deacetylases.
| Molecular Weight | 223.27 |
| Formula | C12H17NO3 |
| CAS Number | 2438-72-4 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Yan Pan, et al. Allergic contact dermatitis to topical preparations of bufexamac
[4] K Waltermann, et al. Bufexamac-induced pigmented purpuric eruption
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