All AbMole products are for research use only, cannot be used for human consumption.
Bucladesine, a membrane permeable selective activator of PKA, has a critical role in up-regulation of ChAT and VAChT gene expression in PC12 cells by activation of extracellular signal regulated kinase (ERK) in Ca2+- and PKA-dependent manner.
Arch Dermatol Res. 2012 May;304(4):313-7.
The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation
Bucladesine Sodium Salt purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | HCT116 cells |
| Preparation method | Cells were treated with 100 μM bucladesine 4 h before harvesting and harvested 48 h after transfection. The levels of indicated factors were determined by immunoblotting. |
| Concentrations | 100 μM |
| Incubation time | 4 h |
| Animal Experiment | |
|---|---|
| Animal models | Adult male Wistar rats |
| Formulation | DMSO and PBS |
| Dosages | 10 and 100 μM |
| Administration | Bucladesine (10 and 100 μM) in a volume of 1 μL/side into both right and left hippocampus was performed before the first training trial in each of four training days |
| Molecular Weight | 492.38 |
| Formula | C18H24N5O8P.Na |
| CAS Number | 16980-89-5 |
| Solubility (25°C) | Water ≥ 34 mg/mL DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] G Wolf. Release of stored retinol from adipocytes
[5] F H Epstein, et al. Na-K-Cl cotransport in chloride-transporting epithelia
| Related PKA Products |
|---|
| 8-Bromo-cAMP sodium salt
8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. |
| H-89 Dihydrochloride
H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM. |
| H-89
H-89 is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. |
| 5-Iodotubercidin
5-IOdotubercidin (NSC 113939), an ATP analogue, is a potent inhibitor of adenosine kinase with an IC50 value of 26 nM. 5-IOdotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by activating phosphorylase and glycogen synthase. 5-IOdotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin inhibitors. |
| HA-100
Ha-100 is a potent protein kinase inhibitor with IC50 values of 4 μM, 8 μM, 12 μM and 240 μM against PKG, PKA, PKC and MLC kinases, respectively. Ha-100 is also used as a ROCK inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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