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Britanin is an NLRP3 inhibitor with an IC50 of 3.630 μM. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK.
| Molecular Weight | 366.41 |
| Formula | C19H26O7 |
| CAS Number | 33627-28-0 |
| Solubility (25°C) | DMSO 150 mg/mL |
| Storage | 4°C, protect from light |
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