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Brincidofovir (CMX001), a lipid-coupled precursor compound of Cidofovir, has long-lasting antiviral effects and is active against a wide range of DNA viruses. These include cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomavirus, papillomavirus, poxvirus, and mixed double-stranded DNA virus infections.
In vivo experiment: (for reference only)
Brincidofovir (CMX001) was suspended in 0.4% carboxymethylcellulose (CMC) for oral delivery to mice. Acyclovir (ACV) was weighed and suspended in sterile water for oral treatment of mice. Compounds were prepared in a 0.2 ml volume which was administered once daily (CMX001) or twice daily (ACV). Treatments for efficacy evaluations were administered to mice for 7 consecutive days beginning 24-72 h post viral inoculation by oral gavage using doses of 5, 2.5 and 1.25 mg/kg of CMX001 administered once daily or doses of 120, 60 or 30 mg/kg of ACV given twice daily at approximately 12 h intervals. For pathogenesis experiments, treatments began 24 h post viral inoculation and were administered for 7 consecutive days using 5 mg/kg of CMX001 or 100 mg/kg of ACV. These doses were selected based upon the results obtained in the mortality experiments.
| Molecular Weight | 561.69 |
| Formula | C27H52N3O7P |
| CAS Number | 444805-28-1 |
| Solubility (25°C) | 0.1 M NaOH: 30 mg/mL |
| Storage | -20°C |
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